Our technologies are the basis for our high-quality products. The selection of the best processes for obtaining stable, highly pure and injection-optimized products is at the heart of the BioScience GmbH team.
Hyaluronic acid (HA) has been used in medicine for a long time and over many years has been proven to have an excellent safety profile. HA, in its natural form, remains in the tissue for only a short amount of time, because of enzymatic degradation and free radical metabolization. To avoid these effects, HA is modified, through crosslinking, to form a water-insoluble polymer hydrogel. This hydrogel is more resistant to degradation, but has a similar biocompatibility to non-modified HA.
For our medical products, we use only hyaluronic acid from reputable manufacturers.
This high purity hyaluronic acid is of non-animal origin and is obtained through biofermentation. This avoids potential foreign protein reactions, which can occur in hyaluronic acids from animal sources.
Every batch of a medical product is tested by an independent laboratory for its endotoxin content (according to the Pharm. Eur. LAL test) and brought to market only when it is verifiably endotoxin free.
BioScience GmbH has developed a specific manufacturing process that allows this special type of cross-linked HA gels to be synthesized. This process creates the property of becoming less viscous under pressure (injecting force) and returning immediately to the original viscosity when the pressure (injecting force) is no longer being applied. This gel's molecules are covalently bonded, meaning it remains in the tissue for longer and is more stable. The special structure of these thixotropic HA molecules also reduces the diffusion rate of the enzyme hyaluronidase into the matrix. As a result of the crosslinking technique, a smooth, homogeneous and long-lasting gel is created.